Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

Open Access

Peer-reviewed

Research Article

Thomas Coudrat,

Affiliation Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Royal Parade, Parkville, Victoria, Australia
⨯
Arthur Christopoulos,

Affiliation Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Royal Parade, Parkville, Victoria, Australia
⨯
Patrick Michael Sexton ,

* E-mail: denise.wootten@monash.edu (DW); patrick.sexton@monash.edu (PMS)

Affiliation Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Royal Parade, Parkville, Victoria, Australia
⨯
Denise Wootten

* E-mail: denise.wootten@monash.edu (DW); patrick.sexton@monash.edu (PMS)

Affiliation Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Royal Parade, Parkville, Victoria, Australia
⨯

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Crystal structure
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G protein coupled receptors
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Computer software
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Library screening
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Enantiomers
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Hydrogen bonding
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Insertion mutation
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Drug interactions
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