Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

Takashi Kasai; Masaki Kondo; Ryotaro Ishii; Akihiro Tanaka; Suzuka Ataka; Hiroyuki Shimada; Takami Tomiyama; Hiroshi Mori; Mark Taylor; David Allsop; Masanori Nakagawa; Toshiki Mizuno; Takahiko Tokuda

doi:10.1371/journal.pone.0174630

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Open Access

Peer-reviewed

Research Article

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

Takashi Kasai ,

* E-mail: ttokuda@koto.kpu-m.ac.jp (TT); kasaita@koto.kpu-m.ac.jp (TK)

Affiliation Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan
⨯
Masaki Kondo,

Affiliation Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan
⨯
Ryotaro Ishii,

Affiliation Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan
⨯
Akihiro Tanaka,

Affiliation Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan
⨯
Suzuka Ataka,

Affiliation Department of Geriatrics and Neurology, Osaka City University graduate school of medicine, Osaka, Japan
⨯
Hiroyuki Shimada,

Affiliation Department of Geriatrics and Neurology, Osaka City University graduate school of medicine, Osaka, Japan
⨯
Takami Tomiyama,

Affiliation Department of Neuroscience, Osaka City University graduate school of medicine, Osaka, Japan
⨯
Hiroshi Mori,

Affiliation Department of Neuroscience, Osaka City University graduate school of medicine, Osaka, Japan
⨯
Mark Taylor,

Affiliation Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kindom
⨯
David Allsop,

Affiliation Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kindom
⨯
Masanori Nakagawa,

Affiliations Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan
⨯
Toshiki Mizuno,

Affiliation Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan
⨯
Takahiko Tokuda

* E-mail: ttokuda@koto.kpu-m.ac.jp (TT); kasaita@koto.kpu-m.ac.jp (TK)

Affiliations Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine,Kyoto, Japan, Department of Molecular Pathobiology of Brain Diseases, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
⨯

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

Takashi Kasai,
Masaki Kondo,
Ryotaro Ishii,
Akihiro Tanaka,
Suzuka Ataka,
Hiroyuki Shimada,
Takami Tomiyama,
Hiroshi Mori,
Mark Taylor,
David Allsop

Published: April 10, 2017
https://doi.org/10.1371/journal.pone.0174630

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Oligomers
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Alzheimer's disease
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Biomarkers
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Cerebrospinal fluid
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Jugular vein
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Receptor antagonist therapy
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Enzyme-linked immunoassays
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