Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats

Ming Zhao; Xin Huang; Xiang Cheng; Xiao Lin; Tong Zhao; Liying Wu; Xiaodan Yu; Kuiwu Wu; Ming Fan; Lingling Zhu

doi:10.1371/journal.pone.0174477

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Open Access

Peer-reviewed

Research Article

Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats

Ming Zhao,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Xin Huang,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Xiang Cheng,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Xiao Lin,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Tong Zhao,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Liying Wu,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Xiaodan Yu,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Kuiwu Wu,

Affiliation Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China
⨯
Ming Fan ,

* E-mail: fanmingchina@126.com (MF); linglingzhu@hotmail.com (LZ)

Affiliations Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, JS, China, Beijing Institute for Brain Disorders, 10 Xitoutiao, You Anmen, Fengtai District, Beijing, P. R. China
⨯
Lingling Zhu

* E-mail: fanmingchina@126.com (MF); linglingzhu@hotmail.com (LZ)

Affiliations Department of Cognitive Science, Beijing Institute of Basic Medical Sciences, Beijing, P.R.China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, JS, China
⨯

Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats

Ming Zhao,
Xin Huang,
Xiang Cheng,
Xiao Lin,
Tong Zhao,
Liying Wu,
Xiaodan Yu,
Kuiwu Wu,
Ming Fan,
Lingling Zhu

Published: March 29, 2017
https://doi.org/10.1371/journal.pone.0174477

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Hypoxia
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Cognitive impairment
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Histones
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Histone acetylation
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