Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin

Feng Wang; Xianfei Ding; Tao Wang; Zhengzheng Shan; Jun Wang; Shaoxuan Wu; Yanyan Chi; Yana Zhang; Zhuan Lv; Liuxing Wang; Qingxia Fan

doi:10.1371/journal.pone.0174276

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Open Access

Peer-reviewed

Research Article

Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin

Feng Wang ,

Contributed equally to this work with: Feng Wang, Xianfei Ding

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Xianfei Ding ,

Contributed equally to this work with: Feng Wang, Xianfei Ding

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Tao Wang,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Zhengzheng Shan,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Jun Wang,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Shaoxuan Wu,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Yanyan Chi,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Yana Zhang,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Zhuan Lv,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Liuxing Wang,

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯
Qingxia Fan

* E-mail: fengw010@163.com

Affiliation Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
⨯

Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin

Feng Wang,
Xianfei Ding,
Tao Wang,
Zhengzheng Shan,
Jun Wang,
Shaoxuan Wu,
Yanyan Chi,
Yana Zhang,
Zhuan Lv,
Liuxing Wang

Published: April 13, 2017
https://doi.org/10.1371/journal.pone.0174276

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