Simultaneous induction of Graves’ hyperthyroidism and Graves’ ophthalmopathy by TSHR genetic immunization in BALB/c mice

Nan Xia; Xiaozhen Ye; Xiaohao Hu; Shiyu Song; Hui Xu; Mengyuan Niu; Hongwei Wang; Jian Wang

doi:10.1371/journal.pone.0174260

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Peer-reviewed

Research Article

Simultaneous induction of Graves’ hyperthyroidism and Graves’ ophthalmopathy by TSHR genetic immunization in BALB/c mice

Nan Xia ,

Contributed equally to this work with: Nan Xia, Xiaozhen Ye

Affiliations Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China, Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, P.R. China, Department of Endocrinology, Mingci Cardiovascular Hospital, Wuxi, P.R. China
⨯
Xiaozhen Ye ,

Contributed equally to this work with: Nan Xia, Xiaozhen Ye

Affiliation Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Xiaohao Hu,

Affiliation Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Shiyu Song,

Affiliation Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Hui Xu,

Affiliation Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Mengyuan Niu,

Affiliation Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Hongwei Wang ,

* E-mail: wangjndcrn@aliyun.com (JW); hwang@nju.edu.cn (HW)

Affiliation Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, P.R. China
⨯
Jian Wang

* E-mail: wangjndcrn@aliyun.com (JW); hwang@nju.edu.cn (HW)

Affiliation Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China
⨯

Simultaneous induction of Graves’ hyperthyroidism and Graves’ ophthalmopathy by TSHR genetic immunization in BALB/c mice

Nan Xia,
Xiaozhen Ye,
Xiaohao Hu,
Shiyu Song,
Hui Xu,
Mengyuan Niu,
Hongwei Wang,
Jian Wang

Published: March 20, 2017
https://doi.org/10.1371/journal.pone.0174260

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