Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

Friedrich Hahn; Adrian Schmalen; Christian Setz; Melanie Friedrich; Stefan Schlößer; Julia Kölle; Robert Spranger; Pia Rauch; Kirsten Fraedrich; Tatjana Reif; Julia Karius-Fischer; Ashok Balasubramanyam; Petra Henklein; Torgils Fossen; Ulrich Schubert

doi:10.1371/journal.pone.0174254

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Open Access

Peer-reviewed

Research Article

Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

Friedrich Hahn ,

Contributed equally to this work with: Friedrich Hahn, Adrian Schmalen

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Adrian Schmalen ,

Contributed equally to this work with: Friedrich Hahn, Adrian Schmalen

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

http://orcid.org/0000-0003-2462-2675

⨯
Christian Setz,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Melanie Friedrich,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Stefan Schlößer,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Julia Kölle,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Robert Spranger,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Pia Rauch,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Kirsten Fraedrich,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

http://orcid.org/0000-0003-4792-4991

⨯
Tatjana Reif,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Julia Karius-Fischer,

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯
Ashok Balasubramanyam,

Affiliation Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Petra Henklein,

Affiliation Institute of Biochemistry, Charité Universitätsmedizin-Berlin, Berlin, Germany
⨯
Torgils Fossen,

Affiliation Department of Chemistry and Centre for Pharmacy, University of Bergen, Bergen, Norway
⨯
Ulrich Schubert

* E-mail: Ulrich.Schubert@viro.med.uni-erlangen.de

Affiliation Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
⨯

Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

Friedrich Hahn,
Adrian Schmalen,
Christian Setz,
Melanie Friedrich,
Stefan Schlößer,
Julia Kölle,
Robert Spranger,
Pia Rauch,
Kirsten Fraedrich,
Tatjana Reif

Published: April 7, 2017
https://doi.org/10.1371/journal.pone.0174254

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