A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

Tenna Ruest Haarmark Nielsen; Emil Vincent Rosenbaum Appel; Mathilde Svendstrup; Johanne Dam Ohrt; Maria Dahl; Cilius Esmann Fonvig; Mette Hollensted; Christian Theil Have; Haja N. Kadarmideen; Oluf Pedersen; Torben Hansen; Jens-Christian Holm; Niels Grarup

doi:10.1371/journal.pone.0174204

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Peer-reviewed

Research Article

A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

Tenna Ruest Haarmark Nielsen ,

Contributed equally to this work with: Tenna Ruest Haarmark Nielsen, Emil Vincent Rosenbaum Appel

Affiliations The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark, The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

http://orcid.org/0000-0002-0684-6651

⨯
Emil Vincent Rosenbaum Appel ,

Contributed equally to this work with: Tenna Ruest Haarmark Nielsen, Emil Vincent Rosenbaum Appel

Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Mathilde Svendstrup,

Affiliations The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Danish Diabetes Academy, Odense, Denmark
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Johanne Dam Ohrt,

Affiliation The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark
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Maria Dahl,

Affiliation The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark
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Cilius Esmann Fonvig,

Affiliations The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark, The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Mette Hollensted,

Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Christian Theil Have,

Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Haja N. Kadarmideen,

Affiliations Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark, Department of Bio and Health Informatics, Technical University of Denmark, Kgs. Lyngby, Denmark
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Oluf Pedersen,

Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Torben Hansen ,

* E-mail: torben.hansen@sund.ku.dk (TH); jhom@regionsjaelland.dk (JCH); niels.grarup@sund.ku.dk (NG)

Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Jens-Christian Holm ,

* E-mail: torben.hansen@sund.ku.dk (TH); jhom@regionsjaelland.dk (JCH); niels.grarup@sund.ku.dk (NG)

Affiliations The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark, The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
⨯
Niels Grarup

* E-mail: torben.hansen@sund.ku.dk (TH); jhom@regionsjaelland.dk (JCH); niels.grarup@sund.ku.dk (NG)

Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

A genome-wide association study of thyroid stimulating hormone and free thyroxine in Danish children and adolescents

Tenna Ruest Haarmark Nielsen,
Emil Vincent Rosenbaum Appel,
Mathilde Svendstrup,
Johanne Dam Ohrt,
Maria Dahl,
Cilius Esmann Fonvig,
Mette Hollensted,
Christian Theil Have,
Haja N. Kadarmideen,
Oluf Pedersen

Published: March 23, 2017
https://doi.org/10.1371/journal.pone.0174204

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Childhood obesity
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Single nucleotide polymorphisms
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Genome-wide association studies
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Genetic loci
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Metaanalysis
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Body mass index
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Thyroid
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