A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model

• Xuan Yuan,

  Affiliation Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Zhe Li,

  Affiliation Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America

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• Andrea C. Baines,

  Affiliation Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Eleni Gavriilaki,

  Affiliation Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Zhaohui Ye,

  Affiliations Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Stem Cell Program in the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Zhexing Wen,

  Affiliation Stem Cell Program in the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Evan M. Braunstein,

  Affiliation Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Leslie G. Biesecker,

  Affiliation Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States of America

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• Linzhao Cheng,

  Affiliations Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Stem Cell Program in the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

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• Xinzhong Dong,

  Affiliation Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, United States of America

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• Robert A. Brodsky

  * E-mail: brodsro@jhmi.edu

  Affiliation Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

  http://orcid.org/0000-0001-5741-1255

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