Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients

Jianfu Heng; Xinwu Guo; Wenhan Wu; Yue Wang; Guoli Li; Ming Chen; Limin Peng; Shouman Wang; Lizhong Dai; Lili Tang; Jun Wang

doi:10.1371/journal.pone.0174022

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Open Access

Peer-reviewed

Research Article

Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients

Jianfu Heng,

Affiliation The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan, China
⨯
Xinwu Guo,

Affiliation Sanway Gene Technology Inc., Changsha, Hunan, China
⨯
Wenhan Wu,

Affiliation The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan, China
⨯
Yue Wang,

Affiliation The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan, China
⨯
Guoli Li,

Affiliation The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan, China
⨯
Ming Chen,

Affiliation Sanway Gene Technology Inc., Changsha, Hunan, China
⨯
Limin Peng,

Affiliation Sanway Gene Technology Inc., Changsha, Hunan, China
⨯
Shouman Wang,

Affiliation Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
⨯
Lizhong Dai,

Affiliations Sanway Gene Technology Inc., Changsha, Hunan, China, Research Center for Technologies in Nucleic Acid-Based Diagnostics, Changsha, Hunan, China, Research Center for Technologies in Nucleic Acid-Based Diagnostics and Therapeutics, Changsha, Hunan, China
⨯
Lili Tang ,

* E-mail: junwang@csu.edu.cn (JW); tlli77@medmail.com.cn (LLT)

Affiliation Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
⨯
Jun Wang

* E-mail: junwang@csu.edu.cn (JW); tlli77@medmail.com.cn (LLT)

Affiliations The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha, Hunan, China, Research Center for Technologies in Nucleic Acid-Based Diagnostics, Changsha, Hunan, China, Research Center for Technologies in Nucleic Acid-Based Diagnostics and Therapeutics, Changsha, Hunan, China
⨯

Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients

Jianfu Heng,
Xinwu Guo,
Wenhan Wu,
Yue Wang,
Guoli Li,
Ming Chen,
Limin Peng,
Shouman Wang,
Lizhong Dai,
Lili Tang

Published: March 16, 2017
https://doi.org/10.1371/journal.pone.0174022

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Breast cancer
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DNA methylation
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Methylation
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Promoter regions
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Breast tumors
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Polymerase chain reaction
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Somatic mutation
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