Highly sensitive measurements of disease progression in rare disorders: Developing and validating a multimodal model of retinal degeneration in Stargardt disease

Stanley Lambertus; Nathalie M. Bax; Ana Fakin; Joannes M. M. Groenewoud; B. Jeroen Klevering; Anthony T. Moore; Michel Michaelides; Andrew R. Webster; Gert Jan van der Wilt; Carel B. Hoyng

doi:10.1371/journal.pone.0174020

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Open Access

Peer-reviewed

Research Article

Highly sensitive measurements of disease progression in rare disorders: Developing and validating a multimodal model of retinal degeneration in Stargardt disease

Stanley Lambertus,

Affiliation Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands

http://orcid.org/0000-0001-9600-9592

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Nathalie M. Bax,

Affiliation Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands
⨯
Ana Fakin,

Affiliation Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
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Joannes M. M. Groenewoud,

Affiliation Department for Health Evidence, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands
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B. Jeroen Klevering,

Affiliation Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands
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Anthony T. Moore,

Affiliation Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
⨯
Michel Michaelides,

Affiliation Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
⨯
Andrew R. Webster,

Affiliation Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
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Gert Jan van der Wilt,

Affiliation Department for Health Evidence, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands
⨯
Carel B. Hoyng

* E-mail: carel.hoyng@radboudumc.nl

Affiliation Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands
⨯

Highly sensitive measurements of disease progression in rare disorders: Developing and validating a multimodal model of retinal degeneration in Stargardt disease

Stanley Lambertus,
Nathalie M. Bax,
Ana Fakin,
Joannes M. M. Groenewoud,
B. Jeroen Klevering,
Anthony T. Moore,
Michel Michaelides,
Andrew R. Webster,
Gert Jan van der Wilt,
Carel B. Hoyng

Published: March 29, 2017
https://doi.org/10.1371/journal.pone.0174020

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