Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

Maolin Sun; Qile Xu; Jingwen Xu; Yue Wu; Yueting Wang; Daiying Zuo; Qi Guan; Kai Bao; Jian Wang; Yingliang Wu; Weige Zhang

doi:10.1371/journal.pone.0174006

Loading metrics

Open Access

Peer-reviewed

Research Article

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

Maolin Sun ,

Contributed equally to this work with: Maolin Sun, Qile Xu

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯
Qile Xu ,

Contributed equally to this work with: Maolin Sun, Qile Xu

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯
Jingwen Xu,

Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Yue Wu,

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯
Yueting Wang,

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯
Daiying Zuo,

Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Qi Guan,

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯
Kai Bao,

Affiliations Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China, Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jian Wang ,

* E-mail: zhangweige2000@sina.com (WZ); jianwang@syphu.edu.cn (JW)

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯
Yingliang Wu,

Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China
⨯
Weige Zhang

* E-mail: zhangweige2000@sina.com (WZ); jianwang@syphu.edu.cn (JW)

Affiliation Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China
⨯

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

Maolin Sun,
Qile Xu,
Jingwen Xu,
Yue Wu,
Yueting Wang,
Daiying Zuo,
Qi Guan,
Kai Bao,
Jian Wang,
Yingliang Wu

Published: March 23, 2017
https://doi.org/10.1371/journal.pone.0174006

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Tubulins
Is the Subject Area "Tubulins" applicable to this article?

Thanks for your feedback.
Polymerization
Is the Subject Area "Polymerization" applicable to this article?

Thanks for your feedback.
Colchicine
Is the Subject Area "Colchicine" applicable to this article?

Thanks for your feedback.
Chemical synthesis
Is the Subject Area "Chemical synthesis" applicable to this article?

Thanks for your feedback.
Gastric cancer
Is the Subject Area "Gastric cancer" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Electrostatics
Is the Subject Area "Electrostatics" applicable to this article?

Thanks for your feedback.
Microtubules
Is the Subject Area "Microtubules" applicable to this article?

Thanks for your feedback.