Screening for interaction effects in gene expression data

Peter J. Castaldi; Michael H. Cho; Liming Liang; Edwin K. Silverman; Craig P. Hersh; Kenneth Rice; Hugues Aschard

doi:10.1371/journal.pone.0173847

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Peer-reviewed

Research Article

Screening for interaction effects in gene expression data

Peter J. Castaldi ,

* E-mail: repjc@channing.harvard.edu (PJC); haschard@hsph.harvard.edu (HA)

Affiliations Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
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Michael H. Cho,

Affiliations Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Liming Liang,

Affiliation Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America
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Edwin K. Silverman,

Affiliations Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Craig P. Hersh,

Affiliations Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Kenneth Rice,

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
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Hugues Aschard

* E-mail: repjc@channing.harvard.edu (PJC); haschard@hsph.harvard.edu (HA)

Affiliations Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America, Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France

http://orcid.org/0000-0002-7554-6783

⨯

Screening for interaction effects in gene expression data

Peter J. Castaldi,
Michael H. Cho,
Liming Liang,
Edwin K. Silverman,
Craig P. Hersh,
Kenneth Rice,
Hugues Aschard

Published: March 16, 2017
https://doi.org/10.1371/journal.pone.0173847

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Gene expression
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Single nucleotide polymorphisms
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Normal distribution
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Genomics
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Strong interaction
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Linear regression analysis
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Genetics
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