Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling

Shannon H. Carroll; Ellen Zhang; Bing F. Wang; Katherine B. LeClair; Arifeen Rahman; David E. Cohen; Jorge Plutzky; Parth Patwari; Richard T. Lee

doi:10.1371/journal.pone.0173823

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Peer-reviewed

Research Article

Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling

Shannon H. Carroll,

Affiliation Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Ellen Zhang,

Affiliation Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Bing F. Wang,

Affiliation Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Katherine B. LeClair,

Affiliation Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Arifeen Rahman,

Affiliation Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
David E. Cohen,

Affiliation Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jorge Plutzky,

Affiliation Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Parth Patwari,

Affiliation Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Richard T. Lee

* E-mail: Richard_Lee@harvard.edu

Affiliations Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, United States of America, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

http://orcid.org/0000-0003-4687-1381

⨯

Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling

Shannon H. Carroll,
Ellen Zhang,
Bing F. Wang,
Katherine B. LeClair,
Arifeen Rahman,
David E. Cohen,
Jorge Plutzky,
Parth Patwari,
Richard T. Lee

Published: March 14, 2017
https://doi.org/10.1371/journal.pone.0173823

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Adrenergic signal transduction
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Adipose tissue
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Gene expression
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Protein expression
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