Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture

Lauren A. Baker; Brian Kirkpatrick; Guilherme J. M. Rosa; Daniel Gianola; Bruno Valente; Julia P. Sumner; Wendy Baltzer; Zhengling Hao; Emily E. Binversie; Nicola Volstad; Alexander Piazza; Susannah J. Sample; Peter Muir

doi:10.1371/journal.pone.0173810

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Open Access

Peer-reviewed

Research Article

Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture

Lauren A. Baker,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Brian Kirkpatrick,

Affiliation Department of Animal Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Guilherme J. M. Rosa,

Affiliation Department of Animal Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Daniel Gianola,

Affiliation Department of Animal Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Bruno Valente,

Affiliations Department of Animal Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, Department of Dairy Sciences, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Julia P. Sumner,

Current address: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America

Affiliation Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
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Wendy Baltzer,

Affiliation Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvalis, Oregon, United States of America
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Zhengling Hao,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Emily E. Binversie,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Nicola Volstad,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Alexander Piazza,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Susannah J. Sample,

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Peter Muir

* E-mail: peter.muir@wisc.edu

Affiliation Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

http://orcid.org/0000-0003-0028-6005

⨯

Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture

Lauren A. Baker,
Brian Kirkpatrick,
Guilherme J. M. Rosa,
Daniel Gianola,
Bruno Valente,
Julia P. Sumner,
Wendy Baltzer,
Zhengling Hao,
Emily E. Binversie,
Nicola Volstad

Published: April 5, 2017
https://doi.org/10.1371/journal.pone.0173810

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Medical risk factors
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Genome-wide association studies
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Genetic loci
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Dogs
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Single nucleotide polymorphisms
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Mammalian genomics
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Pets and companion animals
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Ligaments
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