Lawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation

Yang W. Huan; Rebecca J. Bengtsson; Neil MacIntyre; Jack Guthrie; Heather Finlayson; Sionagh H. Smith; Alan L. Archibald; Tahar Ait-Ali

doi:10.1371/journal.pone.0173782

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Peer-reviewed

Research Article

Lawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation

Yang W. Huan,

Affiliation The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Rebecca J. Bengtsson,

Affiliations The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Neil MacIntyre,

Affiliation Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Jack Guthrie,

Affiliation The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Heather Finlayson,

Affiliations The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Sionagh H. Smith,

Affiliations The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Alan L. Archibald,

Affiliations The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯
Tahar Ait-Ali

* E-mail: tahar.aitali@roslin.ed.ac.uk

Affiliations The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, United Kingdom
⨯

Lawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation

Yang W. Huan,
Rebecca J. Bengtsson,
Neil MacIntyre,
Jack Guthrie,
Heather Finlayson,
Sionagh H. Smith,
Alan L. Archibald,
Tahar Ait-Ali

Published: March 21, 2017
https://doi.org/10.1371/journal.pone.0173782

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Notch signaling
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Swine
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Ileum
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Gastrointestinal tract
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DAPI staining
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Cell proliferation
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