The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant

Sassan Rahnama; Jennifer R. Deuis; Fernanda C. Cardoso; Venkatraman Ramanujam; Richard J. Lewis; Lachlan D. Rash; Glenn F. King; Irina Vetter; Mehdi Mobli

doi:10.1371/journal.pone.0173551

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Open Access

Peer-reviewed

Research Article

The structure, dynamics and selectivity profile of a Na_V1.7 potency-optimised huwentoxin-IV variant

Sassan Rahnama,

Affiliations Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, Australia, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
⨯
Jennifer R. Deuis ,

Contributed equally to this work with: Jennifer R. Deuis, Fernanda C. Cardoso

Affiliation Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
⨯
Fernanda C. Cardoso ,

Contributed equally to this work with: Jennifer R. Deuis, Fernanda C. Cardoso

Affiliation Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
⨯
Venkatraman Ramanujam,

Affiliation Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, Australia
⨯
Richard J. Lewis,

Affiliation Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
⨯
Lachlan D. Rash,

Affiliations Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia, School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia
⨯
Glenn F. King,

Affiliation Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
⨯
Irina Vetter,

Affiliation Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia
⨯
Mehdi Mobli

* E-mail: m.mobli@uq.edu.au

Affiliation Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, Australia

http://orcid.org/0000-0003-2420-4262

⨯

The structure, dynamics and selectivity profile of a Na_V1.7 potency-optimised huwentoxin-IV variant

Sassan Rahnama,
Jennifer R. Deuis,
Fernanda C. Cardoso,
Venkatraman Ramanujam,
Richard J. Lewis,
Lachlan D. Rash,
Glenn F. King,
Irina Vetter,
Mehdi Mobli

Published: March 16, 2017
https://doi.org/10.1371/journal.pone.0173551

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