Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes

Yu Wang; Liying Xuan; Xiaoxue Cui; Yilin Wang; Shaoqing Chen; Chengxi Wei; Ming Zhao

doi:10.1371/journal.pone.0173469

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Peer-reviewed

Research Article

Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes

Yu Wang ,

Contributed equally to this work with: Yu Wang, Liying Xuan

Affiliations Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P.R. China, Inner Mongolia Provincial Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China
⨯
Liying Xuan ,

Contributed equally to this work with: Yu Wang, Liying Xuan

Affiliations Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P.R. China, Inner Mongolia Provincial Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China
⨯
Xiaoxue Cui,

Affiliation First Clinical Medical College of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China
⨯
Yilin Wang,

Affiliation First Clinical Medical College of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China
⨯
Shaoqing Chen,

Affiliation First Clinical Medical College of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China
⨯
Chengxi Wei ,

* E-mail: weichengxi1224@163.com (CXW); langzhe73@163.com (MZ)

Affiliations Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P.R. China, Inner Mongolia Provincial Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China
⨯
Ming Zhao

* E-mail: weichengxi1224@163.com (CXW); langzhe73@163.com (MZ)

Affiliations Inner Mongolia Provincial Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China, First Clinical Medical College of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China
⨯

Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes

Yu Wang,
Liying Xuan,
Xiaoxue Cui,
Yilin Wang,
Shaoqing Chen,
Chengxi Wei,
Ming Zhao

Published: April 11, 2017
https://doi.org/10.1371/journal.pone.0173469

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Apoptosis
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Cardiomyocytes
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Endoplasmic reticulum
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Transfection
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Protein expression
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Small interfering RNA
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Atrial fibrillation
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