ITC-derived binding affinity may be biased due to titrant (nano)-aggregation. Binding of halogenated benzotriazoles to the catalytic domain of human protein kinase CK2

• Maria Winiewska ,

  * E-mail: mwin@ibb.waw.pl (MW); jarek@ibb.waw.pl (JP)

  Affiliation Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

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• Ewa Bugajska,

  Affiliation Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

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• Jarosław Poznański

  * E-mail: mwin@ibb.waw.pl (MW); jarek@ibb.waw.pl (JP)

  Affiliation Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

  http://orcid.org/0000-0003-2684-1775

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