Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

Nele Friedrich; Maik Pietzner; Claire Cannet; Betina H. Thuesen; Torben Hansen; Henri Wallaschofski; Niels Grarup; Tea Skaaby; Kathrin Budde; Oluf Pedersen; Matthias Nauck; Allan Linneberg

doi:10.1371/journal.pone.0173078

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Open Access

Peer-reviewed

Research Article

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

Nele Friedrich ,

* E-mail: nele.friedrich@uni-greifswald.de

Affiliations Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark, Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
⨯
Maik Pietzner,

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
⨯
Claire Cannet,

Affiliation Bruker BioSpin, Rheinstetten, Germany
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Betina H. Thuesen,

Affiliation Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark
⨯
Torben Hansen,

Affiliation Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
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Henri Wallaschofski,

Affiliations Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany, Private Practice Endocrinology, Erfurt, Germany
⨯
Niels Grarup,

Affiliation Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
⨯
Tea Skaaby,

Affiliation Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark
⨯
Kathrin Budde,

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
⨯
Oluf Pedersen,

Affiliation Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
⨯
Matthias Nauck,

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
⨯
Allan Linneberg

Affiliations Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark, Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

Nele Friedrich,
Maik Pietzner,
Claire Cannet,
Betina H. Thuesen,
Torben Hansen,
Henri Wallaschofski,
Niels Grarup,
Tea Skaaby,
Kathrin Budde,
Oluf Pedersen

Published: March 2, 2017
https://doi.org/10.1371/journal.pone.0173078

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Metabolites
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Thyroid-stimulating hormone
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Thyroid
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Urine
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Glycine
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Alanine
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Lactic acid
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Glucose metabolism
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