Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo

Suneel Gupta; Jason T. Rodier; Ajay Sharma; Elizabeth A. Giuliano; Prashant R. Sinha; Nathan P. Hesemann; Arkasubhra Ghosh; Rajiv R. Mohan

doi:10.1371/journal.pone.0172928

Loading metrics

Open Access

Peer-reviewed

Research Article

Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo

Suneel Gupta,

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Jason T. Rodier,

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Mason Eye Institute, School of Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Ajay Sharma,

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America, Chapman University School of Pharmacy, Irvine, California, United States of America
⨯
Elizabeth A. Giuliano,

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Prashant R. Sinha,

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Nathan P. Hesemann,

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Mason Eye Institute, School of Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯
Arkasubhra Ghosh,

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India
⨯
Rajiv R. Mohan

* E-mail: MohanR@health.missouri.edu

Affiliations Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United States of America, Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States of America, Mason Eye Institute, School of Medicine, University of Missouri, Columbia, Missouri, United States of America
⨯

Targeted AAV5-Smad7 gene therapy inhibits corneal scarring in vivo

Suneel Gupta,
Jason T. Rodier,
Ajay Sharma,
Elizabeth A. Giuliano,
Prashant R. Sinha,
Nathan P. Hesemann,
Arkasubhra Ghosh,
Rajiv R. Mohan

Published: March 24, 2017
https://doi.org/10.1371/journal.pone.0172928

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cornea
Is the Subject Area "Cornea" applicable to this article?

Thanks for your feedback.
Rabbits
Is the Subject Area "Rabbits" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Gene delivery
Is the Subject Area "Gene delivery" applicable to this article?

Thanks for your feedback.
Photorefractive keratectomy
Is the Subject Area "Photorefractive keratectomy" applicable to this article?

Thanks for your feedback.
Gene transfer
Is the Subject Area "Gene transfer" applicable to this article?

Thanks for your feedback.
Gene therapy
Is the Subject Area "Gene therapy" applicable to this article?

Thanks for your feedback.