Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

Julia Pollak; Karan G. Rai; Cory C. Funk; Sonali Arora; Eunjee Lee; Jun Zhu; Nathan D. Price; Patrick J. Paddison; Jan-Marino Ramirez; Robert C. Rostomily

doi:10.1371/journal.pone.0172884

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Open Access

Peer-reviewed

Research Article

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

Julia Pollak,

Affiliation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States of America
⨯
Karan G. Rai,

Affiliation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States of America
⨯
Cory C. Funk,

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America
⨯
Sonali Arora,

Affiliation Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Eunjee Lee,

Affiliation Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Jun Zhu,

Affiliations Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Hematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
⨯
Nathan D. Price,

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America
⨯
Patrick J. Paddison,

Affiliation Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Jan-Marino Ramirez,

Affiliations Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States of America, Department of Neurosurgery, University of Washington, Seattle, Washington, United States of America
⨯
Robert C. Rostomily

* E-mail: rrostomily@houstonmethodist.org

Affiliations Department of Neurosurgery, University of Washington, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America, Houston Methodist Research Institute, Houston, Texas, United States of America, Department of Neurosurgery, Houston Methodist Hospital, Houston, Texas, United States of America
⨯

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

Julia Pollak,
Karan G. Rai,
Cory C. Funk,
Sonali Arora,
Eunjee Lee,
Jun Zhu,
Nathan D. Price,
Patrick J. Paddison,
Jan-Marino Ramirez,
Robert C. Rostomily

Published: March 6, 2017
https://doi.org/10.1371/journal.pone.0172884

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Ion channels
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Malignant tumors
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Neurons
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Small interfering RNA
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Gene expression
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