Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern

Pernilla Eliasson; Rene B. Svensson; Antonis Giannopoulos; Christian Eismark; Michael Kjær; Peter Schjerling; Katja M. Heinemeier

doi:10.1371/journal.pone.0172797

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Open Access

Peer-reviewed

Research Article

Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern

Pernilla Eliasson ,

* E-mail: pernilla.eliasson@gmail.com

Affiliations Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

http://orcid.org/0000-0001-6718-034X

⨯
Rene B. Svensson,

Affiliation Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Antonis Giannopoulos,

Affiliation Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Christian Eismark,

Affiliation Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Michael Kjær,

Affiliation Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Peter Schjerling,

Affiliation Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Katja M. Heinemeier

Affiliation Institute of Sports Medicine Copenhagen, Dept of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯

Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern

Pernilla Eliasson,
Rene B. Svensson,
Antonis Giannopoulos,
Christian Eismark,
Michael Kjær,
Peter Schjerling,
Katja M. Heinemeier

Published: March 6, 2017
https://doi.org/10.1371/journal.pone.0172797

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Statins
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Tendons
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Gene expression
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