Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer

Jun Yin; Jian Zhao; Weimin Hu; Guangping Yang; Hui Yu; Ruihao Wang; Linjing Wang; Guoqian Zhang; Wenfan Fu; Lu Dai; Wanzhen Li; Boyu Liao; Shuxu Zhang

doi:10.1371/journal.pone.0172787

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Open Access

Peer-reviewed

Research Article

Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer

Jun Yin ,

Contributed equally to this work with: Jun Yin, Jian Zhao

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Jian Zhao ,

Contributed equally to this work with: Jun Yin, Jian Zhao

Affiliation Department of Chest Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Weimin Hu,

Affiliation Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Guangping Yang,

Affiliation Department of Chest Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Hui Yu,

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Ruihao Wang,

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Linjing Wang,

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Guoqian Zhang,

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Wenfan Fu,

Affiliation Department of Chest Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Lu Dai,

Affiliation Department of Chest Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Wanzhen Li,

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Boyu Liao,

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Shuxu Zhang

* E-mail: tottijun@163.com

Affiliation Department of Radiotherapy, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
⨯

Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer

Jun Yin,
Jian Zhao,
Weimin Hu,
Guangping Yang,
Hui Yu,
Ruihao Wang,
Linjing Wang,
Guoqian Zhang,
Wenfan Fu,
Lu Dai

Published: February 24, 2017
https://doi.org/10.1371/journal.pone.0172787

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