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Open Access

Peer-reviewed

Research Article

Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo

Xiao-dong Pan ,

Contributed equally to this work with: Xiao-dong Pan, Dong-hua Gu, Jia-Hui Mao

Affiliation The Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China
⨯
Dong-hua Gu ,

Contributed equally to this work with: Xiao-dong Pan, Dong-hua Gu, Jia-Hui Mao

Affiliation The Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China
⨯
Jia-Hui Mao ,

Contributed equally to this work with: Xiao-dong Pan, Dong-hua Gu, Jia-Hui Mao

Affiliation Department of pathophysiology, Nantong University School of Medicine, Nantong, China
⨯
Hua Zhu,

Affiliation The Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong, China
⨯
Xinfeng Chen,

Affiliation The Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong, China
⨯
Bing Zheng ,

* E-mail: bingzhengnantong@163.com (BZ); drshanyuxisd@163.com (YS)

Affiliation The Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong, China
⨯
Yuxi Shan

* E-mail: bingzhengnantong@163.com (BZ); drshanyuxisd@163.com (YS)

Affiliation The Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China
⨯

Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo

Xiao-dong Pan,
Dong-hua Gu,
Jia-Hui Mao,
Hua Zhu,
Xinfeng Chen,
Bing Zheng,
Yuxi Shan

x

Published: March 3, 2017
https://doi.org/10.1371/journal.pone.0172555

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Cancers and neoplasms
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Apoptosis
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Kinase inhibitors
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Cancer treatment
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MTT assay
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Epithelial cells
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Genetically modified animals
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