Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques

Juan Pablo Jaworski; Peter Bryk; Zachary Brower; Bo Zheng; Ann J. Hessell; Alexander F. Rosenberg; Tong Tong Wu; Ignacio Sanz; Michael C. Keefer; Nancy L. Haigwood; James J. Kobie

doi:10.1371/journal.pone.0172524

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Open Access

Peer-reviewed

Research Article

Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques

Juan Pablo Jaworski,

Current address: National Institute of Agricultural Technology and National Scientific and Technical Research Council, Buenos Aires, Argentina

Affiliation Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America
⨯
Peter Bryk,

Affiliation Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Zachary Brower,

Affiliation Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America
⨯
Bo Zheng,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Ann J. Hessell,

Affiliation Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America
⨯
Alexander F. Rosenberg,

Affiliation Divsion of Allergy, Immunology & Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Tong Tong Wu,

Affiliation Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Ignacio Sanz,

Affiliation Lowance Center for Human Immunology and Division of Rheumatology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Michael C. Keefer,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Rochester Medical Center, Rochester, New York, United States of America
⨯
Nancy L. Haigwood,

Affiliation Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America
⨯
James J. Kobie

* E-mail: james_kobie@urmc.rocheter.edu

Affiliation Division of Infectious Diseases, Department of Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

http://orcid.org/0000-0001-8069-0272

⨯

Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques

Juan Pablo Jaworski,
Peter Bryk,
Zachary Brower,
Bo Zheng,
Ann J. Hessell,
Alexander F. Rosenberg,
Tong Tong Wu,
Ignacio Sanz,
Michael C. Keefer,
Nancy L. Haigwood

Published: February 21, 2017
https://doi.org/10.1371/journal.pone.0172524

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Antibodies
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Macaque
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Antibody response
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Enzyme-linked immunoassays
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Rhesus monkeys
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