The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

Borbála Vető; Dóra Bojcsuk; Caroline Bacquet; Judit Kiss; Szabolcs Sipeki; Ludovic Martin; László Buday; Bálint L. Bálint; Tamás Arányi

doi:10.1371/journal.pone.0172020

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Peer-reviewed

Research Article

The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

Borbála Vető ,

Contributed equally to this work with: Borbála Vető, Dóra Bojcsuk

Affiliations Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary
⨯
Dóra Bojcsuk ,

Contributed equally to this work with: Borbála Vető, Dóra Bojcsuk

Affiliation Genomic Medicine and Bioinformatic Core Facility, Department of Biochemistry and Molecular Biology, Medical Faculty, University of Debrecen, Debrecen, Hungary
⨯
Caroline Bacquet,

Current address: Amazon Regional University IKIAM, Tena, Ecuador

Affiliation Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
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Judit Kiss,

Affiliation Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
⨯
Szabolcs Sipeki,

Affiliation Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
⨯
Ludovic Martin,

Affiliation CNRS UMR 6214, INSERM U1083, University of Angers, Angers, France
⨯
László Buday,

Affiliations Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
⨯
Bálint L. Bálint,

Affiliation Genomic Medicine and Bioinformatic Core Facility, Department of Biochemistry and Molecular Biology, Medical Faculty, University of Debrecen, Debrecen, Hungary
⨯
Tamás Arányi

* E-mail: aranyi.tamas@ttk.mta.hu

Affiliations Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary, CNRS UMR 6214, INSERM U1083, University of Angers, Angers, France
⨯

The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

Borbála Vető,
Dóra Bojcsuk,
Caroline Bacquet,
Judit Kiss,
Szabolcs Sipeki,
Ludovic Martin,
László Buday,
Bálint L. Bálint,
Tamás Arányi

Published: February 14, 2017
https://doi.org/10.1371/journal.pone.0172020

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Phosphorylation
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Immunoprecipitation
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Transcription factors
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Luciferase
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DNA-binding proteins
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Gene expression
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In vitro kinase assay
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Genomics
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