Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level

• Timo Paavola,

  Affiliation Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland

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• Sanna Kuusisto,

  Current address: NMR metabolomics laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

  Affiliation Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland

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• Matti Jauhiainen,

  Affiliation Genomics and Biomarkers Unit, National Institute for Health and Welfare, Biomedicum, Helsinki, Finland

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• Sakari Kakko,

  Affiliation Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland

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• Tiia Kangas-Kontio,

  Affiliation Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland

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• Jari Metso,

  Affiliation Genomics and Biomarkers Unit, National Institute for Health and Welfare, Biomedicum, Helsinki, Finland

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• Pasi Soininen,

  Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

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• Mika Ala-Korpela,

  Affiliations Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, Oulu University Hospital, Oulu, Finland, Computational Medicine, School of Social and Community Medicine & Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

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• Risto Bloigu,

  Affiliation Medical Informatics and Statistics Research Group, University of Oulu, Oulu, Finland

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• Minna L. Hannuksela,

  Affiliations Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland, Department of Clinical Chemistry, Institute of Diagnostics, University of Oulu, Oulu, Finland

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• Markku J. Savolainen,

  Affiliation Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland

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• Tuire Salonurmi

  * E-mail: tuire.salonurmi@oulu.fi

  Affiliation Department of Internal Medicine, Institute of Clinical Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland and Medical Research Center, Oulu University Hospital, Oulu, Finland

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