Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons

Juan U. Rojo; Michael W. Melkus; Kameswara Rao Kottapalli; Oscar E. Okiya; Justin Sudduth; Weidong Zhang; Adebayo J. Molehin; Darrick Carter; Afzal A. Siddiqui

doi:10.1371/journal.pone.0171677

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Open Access

Peer-reviewed

Research Article

Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons

Juan U. Rojo,

Affiliation Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Lubbock, Texas, United States of America
⨯
Michael W. Melkus,

Affiliation Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Amarillo, Texas, United States of America
⨯
Kameswara Rao Kottapalli,

Affiliation Center for Biotechnology and Genomics. Texas Tech University, Lubbock, Texas, United States of America
⨯
Oscar E. Okiya,

Affiliation Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Lubbock, Texas, United States of America
⨯
Justin Sudduth,

Affiliation Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Lubbock, Texas, United States of America
⨯
Weidong Zhang,

Affiliations Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Lubbock, Texas, United States of America, Department of Internal Medicine. Texas Tech University School of Medicine, Lubbock Texas, United States of America
⨯
Adebayo J. Molehin,

Affiliations Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Lubbock, Texas, United States of America, Department of Internal Medicine. Texas Tech University School of Medicine, Lubbock Texas, United States of America
⨯
Darrick Carter,

Affiliations PAI Life Sciences, Seattle, Washington, United States of America, Infectious Disease Research Institute, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America
⨯
Afzal A. Siddiqui

* E-mail: Afzal.Siddiqui@ttuhsc.edu

Affiliations Center for Tropical Medicine and Infectious Diseases, Texas Tech University School of Medicine, Lubbock, Texas, United States of America, Department of Internal Medicine. Texas Tech University School of Medicine, Lubbock Texas, United States of America
⨯

Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons

Juan U. Rojo,
Michael W. Melkus,
Kameswara Rao Kottapalli,
Oscar E. Okiya,
Justin Sudduth,
Weidong Zhang,
Adebayo J. Molehin,
Darrick Carter,
Afzal A. Siddiqui

Published: February 13, 2017
https://doi.org/10.1371/journal.pone.0171677

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