RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice

Yurong Song; Teresa Sullivan; Kimberly Klarmann; Debra Gilbert; T. Norene O’Sullivan; Lucy Lu; Sophie Wang; Diana C. Haines; Terry Van Dyke; Jonathan R. Keller

doi:10.1371/journal.pone.0171510

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Open Access

Peer-reviewed

Research Article

RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice

Yurong Song,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Teresa Sullivan,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Kimberly Klarmann,

Affiliations Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Debra Gilbert,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
T. Norene O’Sullivan,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Lucy Lu,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Sophie Wang,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Diana C. Haines,

Affiliation Pathology/ Histotechnology Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
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Terry Van Dyke,

Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Jonathan R. Keller

* E-mail: kellerjo@mail.nih.gov

Affiliations Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯

RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice

Yurong Song,
Teresa Sullivan,
Kimberly Klarmann,
Debra Gilbert,
T. Norene O’Sullivan,
Lucy Lu,
Sophie Wang,
Diana C. Haines,
Terry Van Dyke,
Jonathan R. Keller

Published: February 3, 2017
https://doi.org/10.1371/journal.pone.0171510

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