A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element

• Joris van Arensbergen ,

  Contributed equally to this work with: Joris van Arensbergen, Sebastien Dussaud

  Current address: Division of Gene Regulation, Netherlands Cancer Institute, Amsterdam, the Netherlands

  Affiliations Genomic Programming of Beta-Cells Laboratory, IDIBAPS, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas, Barcelona, Spain

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• Sebastien Dussaud ,

  Contributed equally to this work with: Joris van Arensbergen, Sebastien Dussaud

  Current address: Inserm UMRS 1166 Biologie et pharmacologie du remodelage cardiovasculaire, Faculté de médecine Pitié-Salpêtrière, Paris, France

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM)–Hôpital Pitié-Salpêtrière, Boulevard de l’Hôpital, Paris, France

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• Corinne Pardanaud-Glavieux,

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM)–Hôpital Pitié-Salpêtrière, Boulevard de l’Hôpital, Paris, France

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• Javier García-Hurtado,

  Affiliations Genomic Programming of Beta-Cells Laboratory, IDIBAPS, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas, Barcelona, Spain

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• Claire Sauty,

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM)–Hôpital Pitié-Salpêtrière, Boulevard de l’Hôpital, Paris, France

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• Aline Guerci,

  Current address: Agence Nationale de la Recherche, Paris, France

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM)–Hôpital Pitié-Salpêtrière, Boulevard de l’Hôpital, Paris, France

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• Jorge Ferrer ,

  * E-mail: philippe.ravassard@upmc.fr (PR); j.ferrer@imperial.ac.uk (JF)

  Affiliations Genomic Programming of Beta-Cells Laboratory, IDIBAPS, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas, Barcelona, Spain, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Imperial College, London, United Kingdom

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• Philippe Ravassard

  * E-mail: philippe.ravassard@upmc.fr (PR); j.ferrer@imperial.ac.uk (JF)

  Affiliation Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM)–Hôpital Pitié-Salpêtrière, Boulevard de l’Hôpital, Paris, France

  http://orcid.org/0000-0002-0393-9262

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