Differential inhibitory action of apixaban on platelet and fibrin components of forming thrombi: Studies with circulating blood and in a platelet-based model of thrombin generation

• Lluis Pujadas-Mestres ,

  Contributed equally to this work with: Lluis Pujadas-Mestres, Irene Lopez-Vilchez

  Current address: Medical Department, Biogen Spain S.L., Madrid, Spain

  Affiliation Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Centre of Biomedical Diagnosis (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

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• Irene Lopez-Vilchez ,

  Contributed equally to this work with: Lluis Pujadas-Mestres, Irene Lopez-Vilchez

  Affiliation Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Centre of Biomedical Diagnosis (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

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• Eduardo Arellano-Rodrigo,

  Affiliation Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Centre of Biomedical Diagnosis (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

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• Joan Carles Reverter,

  Affiliation Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Centre of Biomedical Diagnosis (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

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• Antonio Lopez-Farre,

  Affiliation Department of Medicine, School of Medicine, Complutense University, Madrid, Spain

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• Maribel Diaz-Ricart,

  Affiliation Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Centre of Biomedical Diagnosis (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

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• Juan Jose Badimon,

  Affiliation Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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• Gines Escolar

  * E-mail: gescolar@clinic.ub.es

  Affiliation Department of Hemotherapy and Hemostasis, Hospital Clinic of Barcelona, Centre of Biomedical Diagnosis (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

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