Characterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis

• María Anguiano ,

  Contributed equally to this work with: María Anguiano, Carlos Castilla

  Affiliation Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain

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• Carlos Castilla ,

  Contributed equally to this work with: María Anguiano, Carlos Castilla

  Affiliation Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain

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• Martin Maška,

  Affiliation Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic

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• Cristina Ederra,

  Affiliation Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain

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• Rafael Peláez,

  Current address: Department of Biomarkers and Molecular Signaling, Division of Oncology, Center for Biomedical Research of La Rioja (CIBIR), Logroño, La Rioja, Spain

  Affiliation Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain

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• Xabier Morales,

  Affiliation Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain

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• Gorka Muñoz-Arrieta,

  Affiliation Biodevices and MEMS group, Water and Health Division, CEIT and TECNUN University of Navarra, Donostia – San Sebastián, Gipuzkoa, SPAIN

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• Maite Mujika,

  Affiliation Biodevices and MEMS group, Water and Health Division, CEIT and TECNUN University of Navarra, Donostia – San Sebastián, Gipuzkoa, SPAIN

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• Michal Kozubek,

  Affiliation Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic

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• Arrate Muñoz-Barrutia,

  Affiliations Bioengineering and Aerospace Engineering Department, Universidad Carlos III de Madrid, Leganes, Madrid, Biomedical Engineering Division, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

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• Ana Rouzaut,

  Affiliations Department of Biochemistry and Genetics, Faculty of Sciences, University of Navarra, Pamplona, Navarra, Spain, Department of Immunology and Inmunotherapy, CIMA, Pamplona, Navarra, Spain

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• Sergio Arana,

  Affiliation Biodevices and MEMS group, Water and Health Division, CEIT and TECNUN University of Navarra, Donostia – San Sebastián, Gipuzkoa, SPAIN

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• José Manuel Garcia-Aznar,

  Affiliation Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

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• Carlos Ortiz-de-Solorzano

  * E-mail: codesolorzano@unav.es

  Affiliation Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain

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