Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats

Simon E. Regnell; Martin J. Hessner; Shuang Jia; Lina Åkesson; Hans Stenlund; Thomas Moritz; Daria La Torre; Åke Lernmark

doi:10.1371/journal.pone.0171372

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Peer-reviewed

Research Article

Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats

Simon E. Regnell ,

* E-mail: simon.regnell@med.lu.se

Affiliation Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University/Clinical Research Centre and Skåne University Hospital, Malmö, Sweden

http://orcid.org/0000-0002-6672-8972

⨯
Martin J. Hessner,

Affiliation Max McGee National Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Shuang Jia,

Affiliation Max McGee National Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Lina Åkesson,

Affiliation Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University/Clinical Research Centre and Skåne University Hospital, Malmö, Sweden
⨯
Hans Stenlund,

Affiliation Swedish Metabolomics Centre, Swedish University of Agricultural Sciences, Umeå, Sweden
⨯
Thomas Moritz,

Affiliation Swedish Metabolomics Centre, Swedish University of Agricultural Sciences, Umeå, Sweden
⨯
Daria La Torre,

Affiliation Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University/Clinical Research Centre and Skåne University Hospital, Malmö, Sweden
⨯
Åke Lernmark

Affiliation Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University/Clinical Research Centre and Skåne University Hospital, Malmö, Sweden
⨯

Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats

Simon E. Regnell,
Martin J. Hessner,
Shuang Jia,
Lina Åkesson,
Hans Stenlund,
Thomas Moritz,
Daria La Torre,
Åke Lernmark

Published: February 13, 2017
https://doi.org/10.1371/journal.pone.0171372

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Diabetes mellitus
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Hyperglycemia
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Lipid metabolism
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Insulin
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Gene expression
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Metabolites
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Gene regulation
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Carbohydrates
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