Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

Tatsuaki Takeda; Hiromasa Yamamoto; Hirotaka Kanzaki; Ken Suzawa; Takahiro Yoshioka; Shuta Tomida; Xiaojiang Cui; Ramachandran Murali; Kei Namba; Hiroki Sato; Hidejiro Torigoe; Mototsugu Watanabe; Kazuhiko Shien; Junichi Soh; Hiroaki Asano; Kazunori Tsukuda; Yoshihisa Kitamura; Shinichiro Miyoshi; Toshiaki Sendo; Shinichi Toyooka

doi:10.1371/journal.pone.0171356

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Peer-reviewed

Research Article

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

Tatsuaki Takeda,

Affiliation Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Hiromasa Yamamoto,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan

http://orcid.org/0000-0002-5330-5460

⨯
Hirotaka Kanzaki,

Affiliation Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Ken Suzawa,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Takahiro Yoshioka,

Affiliation Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Shuta Tomida,

Affiliation Department of Biobank, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Xiaojiang Cui,

Affiliation Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Ramachandran Murali,

Affiliation Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Kei Namba,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Hiroki Sato,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Hidejiro Torigoe,

Affiliations Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan, Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Mototsugu Watanabe,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Kazuhiko Shien,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Junichi Soh,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Hiroaki Asano,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Kazunori Tsukuda,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Yoshihisa Kitamura,

Affiliation Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Shinichiro Miyoshi,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Toshiaki Sendo,

Affiliation Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
[ ... ],
Shinichi Toyooka

* E-mail: toyooka@md.okayama-u.ac.jp

Affiliations Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan, Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
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Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

Tatsuaki Takeda,
Hiromasa Yamamoto,
Hirotaka Kanzaki,
Ken Suzawa,
Takahiro Yoshioka,
Shuta Tomida,
Xiaojiang Cui,
Ramachandran Murali,
Kei Namba,
Hiroki Sato

Published: February 3, 2017
https://doi.org/10.1371/journal.pone.0171356

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