Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro

Yuan Yuan; Zhe Sun; Yi Chen; Yuxin Zheng; Ke-liang Xie; Ying He; Zhifen Wang; Guo-lin Wang; Yong-hao Yu

doi:10.1371/journal.pone.0171348

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Peer-reviewed

Research Article

Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro

Yuan Yuan ,

Contributed equally to this work with: Yuan Yuan, Zhe Sun

¶‡ These authors are co-first authors on this work.

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Zhe Sun ,

Contributed equally to this work with: Yuan Yuan, Zhe Sun

¶‡ These authors are co-first authors on this work.

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Yi Chen,

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Yuxin Zheng,

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Ke-liang Xie,

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Ying He,

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Zhifen Wang,

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Guo-lin Wang,

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯
Yong-hao Yu

* E-mail: family2480@126.com

Affiliations Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin Research Institute of Anesthesiology, Tianjin, China
⨯

Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro

Yuan Yuan,
Zhe Sun,
Yi Chen,
Yuxin Zheng,
Ke-liang Xie,
Ying He,
Zhifen Wang,
Guo-lin Wang,
Yong-hao Yu

Published: February 9, 2017
https://doi.org/10.1371/journal.pone.0171348

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Membrane trafficking
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