Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression

Xiu-Ming Li; Jing-Ru Wang; Tong Shen; Shang-Shang Gao; Xiao-Shun He; Jiang-Nan Li; Tian-Yu Yang; Shen Zhang; Wen-Juan Gan; Jian-Ming Li; Hua Wu

doi:10.1371/journal.pone.0171347

Loading metrics

Open Access

Peer-reviewed

Research Article

Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression

Xiu-Ming Li ,

Contributed equally to this work with: Xiu-Ming Li, Jing-Ru Wang, Tong Shen

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Jing-Ru Wang ,

Contributed equally to this work with: Xiu-Ming Li, Jing-Ru Wang, Tong Shen

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Tong Shen ,

Contributed equally to this work with: Xiu-Ming Li, Jing-Ru Wang, Tong Shen

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Shang-Shang Gao,

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Xiao-Shun He,

Affiliation Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China
⨯
Jiang-Nan Li,

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Tian-Yu Yang,

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Shen Zhang,

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China
⨯
Wen-Juan Gan,

Affiliation Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China
⨯
Jian-Ming Li ,

* E-mail: wuhua@suda.edu.cn (HW); jianmingli@suda.edu.cn (JML)

Affiliation Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Hua Wu

* E-mail: wuhua@suda.edu.cn (HW); jianmingli@suda.edu.cn (JML)

Affiliation Pathology Center and Department of Pathology, Soochow University, Suzhou, China

http://orcid.org/0000-0002-5392-3234

⨯

Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression

Xiu-Ming Li,
Jing-Ru Wang,
Tong Shen,
Shang-Shang Gao,
Xiao-Shun He,
Jiang-Nan Li,
Tian-Yu Yang,
Shen Zhang,
Wen-Juan Gan,
Jian-Ming Li

Published: February 7, 2017
https://doi.org/10.1371/journal.pone.0171347

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Colorectal cancer
Is the Subject Area "Colorectal cancer" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Secondary lung tumors
Is the Subject Area "Secondary lung tumors" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.