Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation

Zoe Loomis; Paul Eigenberger; Katherine Redinius; Christina Lisk; Vijaya Karoor; Eva Nozik-Grayck; Scott K. Ferguson; Kathryn Hassell; Rachelle Nuss; Kurt Stenmark; Paul Buehler; David C. Irwin

doi:10.1371/journal.pone.0171219

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Open Access

Peer-reviewed

Research Article

Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation

Zoe Loomis,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Paul Eigenberger,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Katherine Redinius,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
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Christina Lisk,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Vijaya Karoor,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Eva Nozik-Grayck,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Scott K. Ferguson,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
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Kathryn Hassell,

Affiliation Division of Hematology and Colorado Sickle Cell Treatment and Research Center, University of Colorado-Denver School of Medicine, Aurora, Colorado, United States of America
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Rachelle Nuss,

Affiliation Division of Hematology and Colorado Sickle Cell Treatment and Research Center, University of Colorado-Denver School of Medicine, Aurora, Colorado, United States of America
⨯
Kurt Stenmark,

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
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Paul Buehler,

Affiliation Division of Hematology, The Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland, United States of America
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David C. Irwin

* E-mail: David.irwin@ucdenver.edu

Affiliation Cardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation

Zoe Loomis,
Paul Eigenberger,
Katherine Redinius,
Christina Lisk,
Vijaya Karoor,
Eva Nozik-Grayck,
Scott K. Ferguson,
Kathryn Hassell,
Rachelle Nuss,
Kurt Stenmark

Published: February 2, 2017
https://doi.org/10.1371/journal.pone.0171219

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Heme
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Lipid peroxidation
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Toll-like receptors
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Smooth muscle cells
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Endothelial cells
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Nucleic acids
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Pulmonary vascular diseases
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Pulmonary arteries
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