Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells

Erica S. Lovelace; Nicholas J. Maurice; Hannah W. Miller; Chloe K. Slichter; Robert Harrington; Amalia Magaret; Martin Prlic; Stephen De Rosa; Stephen J. Polyak

doi:10.1371/journal.pone.0171139

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Peer-reviewed

Research Article

Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells

Erica S. Lovelace,

Affiliation Department of Laboratory Medicine, University of Washington, Seattle, WA, United States of America
⨯
Nicholas J. Maurice,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
⨯
Hannah W. Miller,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
⨯
Chloe K. Slichter,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Department of Global Health, University of Washington, Seattle, WA, United States of America
⨯
Robert Harrington,

Affiliation Division of Allergy and Infectious Disease, University of Washington, Seattle, WA, United States of America
⨯
Amalia Magaret,

Affiliations Department of Laboratory Medicine, University of Washington, Seattle, WA, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Department of Biostatistics, University of Washington, Seattle, WA, United States of America
⨯
Martin Prlic,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Department of Global Health, University of Washington, Seattle, WA, United States of America
⨯
Stephen De Rosa,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
⨯
Stephen J. Polyak

* E-mail: polyak@uw.edu

Affiliations Department of Laboratory Medicine, University of Washington, Seattle, WA, United States of America, Department of Global Health, University of Washington, Seattle, WA, United States of America, Department of Microbiology, University of Washington, Seattle, WA, United States of America
⨯

Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells

Erica S. Lovelace,
Nicholas J. Maurice,
Hannah W. Miller,
Chloe K. Slichter,
Robert Harrington,
Amalia Magaret,
Martin Prlic,
Stephen De Rosa,
Stephen J. Polyak

Published: February 3, 2017
https://doi.org/10.1371/journal.pone.0171139

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