A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Adam Yasgar; Steven A. Titus; Yuhong Wang; Carina Danchik; Shyh-Ming Yang; Vasilis Vasiliou; Ajit Jadhav; David J. Maloney; Anton Simeonov; Natalia J. Martinez

doi:10.1371/journal.pone.0170937

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Open Access

Peer-reviewed

Research Article

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Adam Yasgar,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Steven A. Titus,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Yuhong Wang,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Carina Danchik,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Shyh-Ming Yang,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Vasilis Vasiliou,

Affiliation Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, United States of America
⨯
Ajit Jadhav,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
David J. Maloney,

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Anton Simeonov ,

* E-mail: asimeono@mail.nih.gov (AS); natalia.martinez@nih.gov (NJM)

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯
Natalia J. Martinez

* E-mail: asimeono@mail.nih.gov (AS); natalia.martinez@nih.gov (NJM)

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States of America
⨯

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Adam Yasgar,
Steven A. Titus,
Yuhong Wang,
Carina Danchik,
Shyh-Ming Yang,
Vasilis Vasiliou,
Ajit Jadhav,
David J. Maloney,
Anton Simeonov,
Natalia J. Martinez

Published: January 27, 2017
https://doi.org/10.1371/journal.pone.0170937

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