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Open Access

Peer-reviewed

Research Article

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

Wafa Zeriouh ,

Contributed equally to this work with: Wafa Zeriouh, Abdelhafid Nani

Affiliation Laboratory of Natural Products, Aboubekr Belkaid University, Tlemcen, Algeria
⨯
Abdelhafid Nani ,

Contributed equally to this work with: Wafa Zeriouh, Abdelhafid Nani

Affiliations Laboratory of Natural Products, Aboubekr Belkaid University, Tlemcen, Algeria, Department of Natural and Life Sciences, African University Ahmed Draia, Adrar, Algeria, INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Meriem Belarbi,

Affiliation Laboratory of Natural Products, Aboubekr Belkaid University, Tlemcen, Algeria
⨯
Adélie Dumont,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Charlotte de Rosny,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Ikram Aboura,

Affiliations Laboratory of Natural Products, Aboubekr Belkaid University, Tlemcen, Algeria, INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Fatima Zahra Ghanemi,

Affiliations Laboratory of Natural Products, Aboubekr Belkaid University, Tlemcen, Algeria, INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Babar Murtaza,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Danish Patoli,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Charles Thomas,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Lionel Apetoh,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Cédric Rébé,

Affiliations INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France, Centre Georges François Leclerc, Dijon, France
⨯
Dominique Delmas,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
Naim Akhtar Khan,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
François Ghiringhelli,

Affiliations INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France, Centre Georges François Leclerc, Dijon, France
⨯
Mickael Rialland,

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
[ ... ],
Aziz Hichami

* E-mail: aziz.hichami@u-bourgogne.fr

Affiliation INSERM U1231, Université de Bourgogne Franche-Comté, Dijon, France
⨯
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Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

Wafa Zeriouh,
Abdelhafid Nani,
Meriem Belarbi,
Adélie Dumont,
Charlotte de Rosny,
Ikram Aboura,
Fatima Zahra Ghanemi,
Babar Murtaza,
Danish Patoli,
Charles Thomas

x

Published: February 17, 2017
https://doi.org/10.1371/journal.pone.0170823

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Apoptosis
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Colorectal cancer
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Mitochondria
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Cancer treatment
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Leaves
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Phenols
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Mouse models
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Malignant tumors
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