Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing

Michael T. Zimmermann; Raul Urrutia; Gavin R. Oliver; Patrick R. Blackburn; Margot A. Cousin; Nicole J. Bozeck; Eric W. Klee

doi:10.1371/journal.pone.0170822

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Peer-reviewed

Research Article

Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing

Michael T. Zimmermann,

Affiliation Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States of America

http://orcid.org/0000-0001-7073-0525

⨯
Raul Urrutia ,

* E-mail: urrutia.raul@mayo.edu (RU); klee.eric@mayo.edu (EWK)

Affiliations Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Gavin R. Oliver,

Affiliations Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States of America, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States of America
⨯
Patrick R. Blackburn,

Affiliation Center for Individualized Medicine, Mayo Clinic, Jacksonville, FL, United States of America

http://orcid.org/0000-0003-0658-1275

⨯
Margot A. Cousin,

Affiliations Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States of America, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States of America
⨯
Nicole J. Bozeck,

Affiliation Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States of America
⨯
Eric W. Klee

* E-mail: urrutia.raul@mayo.edu (RU); klee.eric@mayo.edu (EWK)

Affiliations Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States of America, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States of America
⨯

Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing

Michael T. Zimmermann,
Raul Urrutia,
Gavin R. Oliver,
Patrick R. Blackburn,
Margot A. Cousin,
Nicole J. Bozeck,
Eric W. Klee

Published: February 9, 2017
https://doi.org/10.1371/journal.pone.0170822

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