Promoter Methylation Pattern Controls Corticotropin Releasing Hormone Gene Activity in Human Trophoblasts

Xin Pan; Maria Bowman; Rodney J. Scott; John Fitter; Roger Smith; Tamas Zakar

doi:10.1371/journal.pone.0170671

Loading metrics

Open Access

Peer-reviewed

Research Article

Promoter Methylation Pattern Controls Corticotropin Releasing Hormone Gene Activity in Human Trophoblasts

Xin Pan,

Current address: Department of Obstetrics and Gynaecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China

Affiliations Mothers and Babies Research Centre, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia, Priority Research Centre for Reproductive Science, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia
⨯
Maria Bowman,

Affiliation Mothers and Babies Research Centre, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia
⨯
Rodney J. Scott,

Affiliations Priority Research Centre for Reproductive Science, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia, Molecular Medicine, Hunter Area Pathology Service, New Lambton Heights, NSW, Australia
⨯
John Fitter,

Affiliations Mothers and Babies Research Centre, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia, Priority Research Centre for Reproductive Science, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia
⨯
Roger Smith,

Affiliations Mothers and Babies Research Centre, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia, Priority Research Centre for Reproductive Science, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia, John Hunter Hospital, New Lambton Heights, NSW, Australia
⨯
Tamas Zakar

* E-mail: Tamas.Zakar@newcastle.edu.au

Affiliations Mothers and Babies Research Centre, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia, Priority Research Centre for Reproductive Science, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia, John Hunter Hospital, New Lambton Heights, NSW, Australia

http://orcid.org/0000-0002-1690-1159

⨯

Promoter Methylation Pattern Controls Corticotropin Releasing Hormone Gene Activity in Human Trophoblasts

Xin Pan,
Maria Bowman,
Rodney J. Scott,
John Fitter,
Roger Smith,
Tamas Zakar

Published: February 2, 2017
https://doi.org/10.1371/journal.pone.0170671

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Trophoblasts
Is the Subject Area "Trophoblasts" applicable to this article?

Thanks for your feedback.
Histone modification
Is the Subject Area "Histone modification" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
DNA transcription
Is the Subject Area "DNA transcription" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.
Pregnancy
Is the Subject Area "Pregnancy" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.