25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

Zaki K. Hassan-Smith; Carl Jenkinson; David J. Smith; Ivan Hernandez; Stuart A. Morgan; Nicola J. Crabtree; Neil J. Gittoes; Brian G. Keevil; Paul M. Stewart; Martin Hewison

doi:10.1371/journal.pone.0170665

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Open Access

Peer-reviewed

Research Article

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

Zaki K. Hassan-Smith,

Affiliations Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom, Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom, Department of Endocrinology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
⨯
Carl Jenkinson,

Affiliation Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom
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David J. Smith,

Affiliations Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom, School of Mathematics, University of Birmingham, Birmingham, United Kingdom
⨯
Ivan Hernandez,

Affiliation Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom
⨯
Stuart A. Morgan,

Affiliation Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom
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Nicola J. Crabtree,

Affiliation Department of Nuclear Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
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Neil J. Gittoes,

Affiliations Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom, Department of Endocrinology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
⨯
Brian G. Keevil,

Affiliation Department of Clinical Biochemistry, University Hospital South Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
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Paul M. Stewart,

Affiliation Faculty of Medicine and Health, Worsley Building, University of Leeds, Leeds, United Kingdom
⨯
Martin Hewison

* E-mail: m.hewison@bham.ac.uk

Affiliations Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom, Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom

http://orcid.org/0000-0001-5806-9690

⨯

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

Zaki K. Hassan-Smith,
Carl Jenkinson,
David J. Smith,
Ivan Hernandez,
Stuart A. Morgan,
Nicola J. Crabtree,
Neil J. Gittoes,
Brian G. Keevil,
Paul M. Stewart,
Martin Hewison

Published: February 15, 2017
https://doi.org/10.1371/journal.pone.0170665

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19 Feb 2017
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Vitamin D
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Metabolites
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Muscle functions
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Skeletal muscles
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Adipose tissue
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Gene expression
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Biopsy
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Muscle analysis
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