Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

Ikuko Takahara; Yuko Akazawa; Maiko Tabuchi; Katsuya Matsuda; Hisamitsu Miyaaki; Youko Kido; Yasuko Kanda; Naota Taura; Ken Ohnita; Fuminao Takeshima; Yusuke Sakai; Susumu Eguchi; Masahiro Nakashima; Kazuhiko Nakao

doi:10.1371/journal.pone.0170591

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Open Access

Peer-reviewed

Research Article

Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

Ikuko Takahara,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Yuko Akazawa ,

* E-mail: akazaway@nagasaki-u.ac.jp

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Maiko Tabuchi,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Katsuya Matsuda,

Affiliation Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
⨯
Hisamitsu Miyaaki,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Youko Kido,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Yasuko Kanda,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Naota Taura,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Ken Ohnita,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Fuminao Takeshima,

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯
Yusuke Sakai,

Affiliation Department of Surgery, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan
⨯
Susumu Eguchi,

Affiliation Department of Surgery, Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan
⨯
Masahiro Nakashima,

Affiliation Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
⨯
Kazuhiko Nakao

Affiliation Division of Gastroenterology and Hepatology, Nagasaki University School of Medicine, Nagasaki, Japan
⨯

Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

Ikuko Takahara,
Yuko Akazawa,
Maiko Tabuchi,
Katsuya Matsuda,
Hisamitsu Miyaaki,
Youko Kido,
Yasuko Kanda,
Naota Taura,
Ken Ohnita,
Fuminao Takeshima

Published: March 9, 2017
https://doi.org/10.1371/journal.pone.0170591

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