Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

Hsien-Chuen Soo; Felicia Fei-Lei Chung; Kuan-Hon Lim; Veronica Alicia Yap; Tracey D. Bradshaw; Ling-Wei Hii; Si-Hoey Tan; Sze-Jia See; Yuen-Fen Tan; Chee-Onn Leong; Chun-Wai Mai

doi:10.1371/journal.pone.0170551

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Peer-reviewed

Research Article

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

Hsien-Chuen Soo,

Affiliation School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Felicia Fei-Lei Chung,

Affiliation Center for Cancer and Stem Cell Research, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Kuan-Hon Lim,

Affiliation School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih, Selangor, Malaysia
⨯
Veronica Alicia Yap,

Affiliation School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih, Selangor, Malaysia
⨯
Tracey D. Bradshaw,

Affiliation School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
⨯
Ling-Wei Hii,

Affiliation School of Postgraduate Studies, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Si-Hoey Tan,

Affiliation School of Postgraduate Studies, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Sze-Jia See,

Affiliation Center for Cancer and Stem Cell Research, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Yuen-Fen Tan,

Affiliation School of Postgraduate Studies, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Chee-Onn Leong,

Affiliations Center for Cancer and Stem Cell Research, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia
⨯
Chun-Wai Mai

* E-mail: chunwai_mai@imu.edu.my

Affiliation School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia

http://orcid.org/0000-0001-6532-184X

⨯

Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

Hsien-Chuen Soo,
Felicia Fei-Lei Chung,
Kuan-Hon Lim,
Veronica Alicia Yap,
Tracey D. Bradshaw,
Ling-Wei Hii,
Si-Hoey Tan,
Sze-Jia See,
Yuen-Fen Tan,
Chee-Onn Leong

Published: January 20, 2017
https://doi.org/10.1371/journal.pone.0170551

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Colorectal cancer
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Apoptosis
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Cancer treatment
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Signal inhibition
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Gene expression
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Caco-2 cells
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Oncogenic signaling
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