Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA

Qun Wang; Yan Chen; Romana Cvitkovic; Meghan E. Pennini; Chew shun Chang; Mark Pelletier; Jessica Bonnell; Adem C. Koksal; Herren Wu; William F. Dall’Acqua; C. Kendall Stover; Xiaodong Xiao

doi:10.1371/journal.pone.0170529

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Open Access

Peer-reviewed

Research Article

Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA

Qun Wang,

Affiliation Dept. of Infectious Disease and Vaccines, MedImmune, Gaithersburg, MD, United States of America
⨯
Yan Chen,

Affiliation Dept. of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, United States of America
⨯
Romana Cvitkovic,

Affiliation Dept. of Infectious Disease and Vaccines, MedImmune, Gaithersburg, MD, United States of America
⨯
Meghan E. Pennini,

Affiliation Dept. of Infectious Disease and Vaccines, MedImmune, Gaithersburg, MD, United States of America
⨯
Chew shun Chang,

Affiliation Dept. of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, United States of America
⨯
Mark Pelletier,

Affiliation Dept. of Infectious Disease and Vaccines, MedImmune, Gaithersburg, MD, United States of America
⨯
Jessica Bonnell,

Affiliation Dept. of Infectious Disease and Vaccines, MedImmune, Gaithersburg, MD, United States of America
⨯
Adem C. Koksal,

Affiliation Dept. of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, United States of America

http://orcid.org/0000-0002-3163-7421

⨯
Herren Wu,

Affiliation Dept. of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, United States of America
⨯
William F. Dall’Acqua,

Affiliation Dept. of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, United States of America
⨯
C. Kendall Stover,

Affiliation Dept. of Infectious Disease and Vaccines, MedImmune, Gaithersburg, MD, United States of America
⨯
Xiaodong Xiao

* E-mail: xiaox@medimmune.com

Affiliation Dept. of Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, United States of America
⨯

Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA

Qun Wang,
Yan Chen,
Romana Cvitkovic,
Meghan E. Pennini,
Chew shun Chang,
Mark Pelletier,
Jessica Bonnell,
Adem C. Koksal,
Herren Wu,
William F. Dall’Acqua

Published: January 20, 2017
https://doi.org/10.1371/journal.pone.0170529

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