High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer

John J. Wallbillich; Srirama Josyula; Uksha Saini; Roman A. Zingarelli; Kalpana Deepa Priya Dorayappan; Maria K. Riley; Ross A. Wanner; David E. Cohn; Karuppaiyah Selvendiran

doi:10.1371/journal.pone.0170318

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Open Access

Peer-reviewed

Research Article

High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer

John J. Wallbillich,

Current address: Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia, United States of America

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Srirama Josyula,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
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Uksha Saini,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
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Roman A. Zingarelli,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
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Kalpana Deepa Priya Dorayappan,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Maria K. Riley,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Ross A. Wanner,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
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David E. Cohn,

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Karuppaiyah Selvendiran

* E-mail: selvendiran.karuppaiyah@osumc.edu

Affiliation Division of Gynecologic Oncology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯

High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer

John J. Wallbillich,
Srirama Josyula,
Uksha Saini,
Roman A. Zingarelli,
Kalpana Deepa Priya Dorayappan,
Maria K. Riley,
Ross A. Wanner,
David E. Cohn,
Karuppaiyah Selvendiran

Published: January 23, 2017
https://doi.org/10.1371/journal.pone.0170318

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