Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer’s Disease

• Ksenia V. Kastanenka ,

  * E-mail: bbacskai@mgh.harvard.edu (BJB); kkastanenka@mgh.harvard.edu (KVK)

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Steven S. Hou,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Naomi Shakerdge,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Robert Logan,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Danielle Feng,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Susanne Wegmann,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Vanita Chopra,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Jonathan M. Hawkes,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Xiqun Chen,

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯
• Brian J. Bacskai

  * E-mail: bbacskai@mgh.harvard.edu (BJB); kkastanenka@mgh.harvard.edu (KVK)

  Affiliation Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States of America

  ⨯