Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells

Ibrahim Malami; Ahmad Bustamam Abdul; Rasedee Abdullah; Nur Kartinee Bt Kassim; Rozita Rosli; Swee Keong Yeap; Peter Waziri; Imaobong Christopher Etti; Muhammad Bashir Bello

doi:10.1371/journal.pone.0170233

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Research Article

Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells

Ibrahim Malami ,

Contributed equally to this work with: Ibrahim Malami, Ahmad Bustamam Abdul

* E-mail: keepibinformed@yahoo.co.uk (IM); zer2crystals@gmail.com (ABA)

Affiliations Laboratory of MAKNA-Cancer Research, Institute of Bioscience, Universiti Putra Malaysia Serdang, Selangor, Malaysia, Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
⨯
Ahmad Bustamam Abdul ,

Contributed equally to this work with: Ibrahim Malami, Ahmad Bustamam Abdul

* E-mail: keepibinformed@yahoo.co.uk (IM); zer2crystals@gmail.com (ABA)

Affiliations Laboratory of MAKNA-Cancer Research, Institute of Bioscience, Universiti Putra Malaysia Serdang, Selangor, Malaysia, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
⨯
Rasedee Abdullah,

Affiliation Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia Serdang, Selangor, Malaysia
⨯
Nur Kartinee Bt Kassim,

Affiliation Department of Chemistry, Faculty of Science, Universiti Putra Malaysia Serdang, Selangor, Malaysia
⨯
Rozita Rosli,

Affiliations Laboratory of MAKNA-Cancer Research, Institute of Bioscience, Universiti Putra Malaysia Serdang, Selangor, Malaysia, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
⨯
Swee Keong Yeap,

Affiliation Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia Serdang, Selangor, Malaysia
⨯
Peter Waziri,

Affiliation Laboratory of MAKNA-Cancer Research, Institute of Bioscience, Universiti Putra Malaysia Serdang, Selangor, Malaysia
⨯
Imaobong Christopher Etti,

Affiliation Department of Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia Serdang, Selangor, Malaysia
⨯
Muhammad Bashir Bello

Affiliation Department of Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia Serdang, Selangor, Malaysia
⨯

Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells

Ibrahim Malami,
Ahmad Bustamam Abdul,
Rasedee Abdullah,
Nur Kartinee Bt Kassim,
Rozita Rosli,
Swee Keong Yeap,
Peter Waziri,
Imaobong Christopher Etti,
Muhammad Bashir Bello

Published: January 19, 2017
https://doi.org/10.1371/journal.pone.0170233

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