Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation

Stephane Esnault; Elizabeth E. Torr; Ksenija Bernau; Mats W. Johansson; Elizabeth A. Kelly; Nathan Sandbo; Nizar N. Jarjour

doi:10.1371/journal.pone.0170207

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Peer-reviewed

Research Article

Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation

Stephane Esnault ,

* E-mail: sesnault@medicine.wisc.edu

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Elizabeth E. Torr,

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Ksenija Bernau,

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Mats W. Johansson,

Affiliation Department of Biomolecular Chemistry, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Elizabeth A. Kelly,

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Nathan Sandbo ,

¶‡ These authors contributed equally as senior authors.

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Nizar N. Jarjour

¶‡ These authors contributed equally as senior authors.

Affiliation Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, the University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯

Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation

Stephane Esnault,
Elizabeth E. Torr,
Ksenija Bernau,
Mats W. Johansson,
Elizabeth A. Kelly,
Nathan Sandbo,
Nizar N. Jarjour

Published: January 17, 2017
https://doi.org/10.1371/journal.pone.0170207

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Fibroblasts
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Small interfering RNA
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Pulmonary fibrosis
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Gene expression
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ERK signaling cascade
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